Linked Life Data

8093690

Source:http://linkedlifedata.com/resource/pubmed/id/8093690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-25
pubmed:databankReference
pubmed:abstractText
Viable aristaless (al) mutations of Drosophila affect pattern elements at both ends of the proximodistal axis in a subset of adult appendages. The al gene has been cloned and identified by P-element-mediated germ-line transformation with a genomic DNA fragment, which rescues a lethal mutation of al as well as aspects of the adult al phenotype. The al gene contains a prd-type homeo domain and a Pro/Gln-rich domain and, hence, probably encodes a transcription factor. Its transcript distribution in third-instar imaginal discs closely corresponds to the anlagen of the tissues that later become visibly affected in adult al mutants. The striking similarity of a bimodal al expression in different imaginal discs indicates that al is under the control of a "prepattern," which is shared at least among antennal, leg, and wing discs. The al gene is also transcribed during embryogenesis. Apart from a function in the ontogeny of specific larval head and tail organs, its embryonic transcript pattern suggests a possible role in early imaginal disc development.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0890-9369
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:geneSymbol
prd
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-29
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila.
pubmed:affiliation
Institute for Molecular Biology II, University of Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't