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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-10-3
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pubmed:abstractText |
The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-kappa B transcription factor, which is thought to depend on the presence of reactive oxygen intermediates. In mouse L cells, overexpression of Bcl-2 interfered with the activation of NF-kappa B by H2O2. However, Bcl-2 had no effect on the activation of NF-kappa B by TNF, even though it protected cells from TNF-induced apoptosis. The effects of exogenous pyrrolidine dithiocarbamate were very similar to those of Bcl-2 overexpression. We conclude that the protective effects of anti-oxidants against induced apoptotic cell death are unrelated to their ability to interfere with NF-kappa B activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
351
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8076691-Animals,
pubmed-meshheading:8076691-Antioxidants,
pubmed-meshheading:8076691-Apoptosis,
pubmed-meshheading:8076691-Base Sequence,
pubmed-meshheading:8076691-Cell Line,
pubmed-meshheading:8076691-L Cells (Cell Line),
pubmed-meshheading:8076691-Mice,
pubmed-meshheading:8076691-Molecular Sequence Data,
pubmed-meshheading:8076691-NF-kappa B,
pubmed-meshheading:8076691-Oligodeoxyribonucleotides,
pubmed-meshheading:8076691-Protein-Tyrosine Kinases,
pubmed-meshheading:8076691-Proto-Oncogene Proteins,
pubmed-meshheading:8076691-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8076691-Reactive Oxygen Species,
pubmed-meshheading:8076691-Tumor Necrosis Factor-alpha
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pubmed:year |
1994
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pubmed:articleTitle |
Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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