Linked Life Data

8074452

Source:http://linkedlifedata.com/resource/pubmed/id/8074452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3A
pubmed:dateCreated
1994-9-26
pubmed:abstractText
The lack of metastatic behaviour of primary glioma is poorly understood. A possible natural barrier accounting for this phenomenon may be the proteins of the extracellular matrix which are found in the basement membranes of the blood vascular system. This hypothesis is reinforced by the finding that glioma invasion in vitro using a syngeneic model system results in a lack of invasion of areas of target tissue which contain extracellular matrix proteins. The study was extended by examining the effect of the incorporation of these proteins during the formation of fetal rat brain cell aggregates and glioma spheroids and on the invasion of aggregates by tumour spheroids. Laminin was shown to reduce the size of the aggregates and spheroids during their formation while fibronectin and type IV collagen had no effect. Laminin also prevented the invasion of the tumour spheroid into the target aggregate and appeared to inhibit migration of glioma cells on laminin coated tissue culture plastic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1071-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Laminin: a potential inhibitor of rat glioma cell invasion in vitro.
pubmed:affiliation
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't