Linked Life Data

8072446

Source:http://linkedlifedata.com/resource/pubmed/id/8072446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-9-28
pubmed:abstractText
Concentrations of free and acid-labile carbon disulfide in human blood were determined by gas chromatography mass-spectrometry. Carbon disulfide was measured in the blood of 62 subjects not occupationally exposed to the solvent, and in 27 subjects treated with disulfiram (which is partially biotransformed into carbon disulfide). In blood, a small part of carbon disulfide is free (it can be analysed without any blood treatment); most carbon disulfide is bound ("acid labile" carbon disulfide), and requires acid hydrolysis to become free and detectable. During the first phase of our study, stored samples of blood (storage at 4 degrees C for 15-40 days) were used. Later, we analysed fresh blood samples. A significant decrease in carbon disulfide was found in stored samples in comparison to fresh samples. During storage, free and acid-labile carbon disulfide in blood decreased respectively to 26% and 27% of the initial concentration within a month. In fresh samples, free carbon disulfide concentrations in blood showed a median of 139 ng/l in normal subjects. Acid-labile carbon disulfide concentrations were much higher (median 2743 ng/l). Free and acid-labile carbon disulfide in blood were closely correlated (r = 0.9358). Blood samples stored at -80 degrees C maintained a constant concentration of carbon disulfide over almost three weeks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7818
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Carbon disulfide in blood: a method for storing and analysing samples.
pubmed:affiliation
Institute of Occupational Medicine, University of Verona, Policlinico Borgo Roma, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't