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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1994-9-21
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pubmed:abstractText |
We have discovered a new DNA endonuclease in the fission yeast Schizosaccharomyces pombe which recognizes cyclobutane pyrimidine dimers and (6-4) pyrimidine-pyrimidone photoproducts. S. pombe DNA endonuclease (SPDE) catalyzes a single ATP-independent incision immediately 5' to the UV photoproduct and generates termini containing 3' hydroxyl and 5' phosphoryl groups. Based on these properties, we propose that SPDE may function in a DNA repair capacity, representing the initial recognition/cleavage step of a DNA excision repair pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-1373868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-1465447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-1655020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-2168423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-2181258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-2295120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-2457204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-2987881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-4610149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-5543985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-6253795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-6325459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-6814504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-7142164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-7335493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-795416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-8426655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-8496175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065916-8506335
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3026-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8065916-Adenosine Triphosphate,
pubmed-meshheading:8065916-Base Sequence,
pubmed-meshheading:8065916-DNA,
pubmed-meshheading:8065916-DNA Damage,
pubmed-meshheading:8065916-DNA Repair,
pubmed-meshheading:8065916-Endodeoxyribonucleases,
pubmed-meshheading:8065916-Molecular Sequence Data,
pubmed-meshheading:8065916-Photochemistry,
pubmed-meshheading:8065916-Pyrimidine Dimers,
pubmed-meshheading:8065916-Schizosaccharomyces,
pubmed-meshheading:8065916-Schizosaccharomyces pombe Proteins,
pubmed-meshheading:8065916-Substrate Specificity,
pubmed-meshheading:8065916-Ultraviolet Rays
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pubmed:year |
1994
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pubmed:articleTitle |
A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6-4 photoproducts.
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pubmed:affiliation |
Department of Biochemistry, Emory University School of Medicine, Rollins Research Center, Atlanta, GA 30322.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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