Pyrimidine Dimers

Source:http://linkedlifedata.com/resource/umls/id/C0034286

MSH: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.,CSP: covalently linked adjacent pyrimidine bases (usually thymidine) on a strand of DNA produced by UV light or other radiation; the mutation blocks both transcription and replication until excised and repaired.,NCI: A dimer consisting of two adjacent pyrimidines covalently jointed by a cyclobutane ring, inhibiting DNA replication.

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