Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-22
pubmed:abstractText
Tumor necrosis factor (TNF) alpha is a cytokine that has potent immune regulatory functions. To assess the potential role of this cytokine in the early development of autoimmunity, we investigated the effect of TNF on the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice, a spontaneous murine model for autoimmune, insulin-dependent type I diabetes. Treatment of newborn female NOD mice with TNF every other day for 3 wk, led to an earlier onset of disease (10 versus 15 wk of age in control mice) and 100% incidence before 20 wk of age (compared to 45% at 20 wk of age in control phosphate-buffered saline treated female mice). In contrast, administration of an anti-TNF monoclonal antibody, TN3.19.12, resulted in complete prevention of IDDM. In vitro proliferation assays demonstrated that mice treated with TNF developed an increased T cell response to a panel of beta cell autoantigens, whereas anti-TNF treatment resulted in unresponsiveness to the autoantigens. In addition, autoantibody responses to the panel of beta cell antigens paralleled the T cell responses. The effects mediated by TNF appear to be highly age dependent. Treatment of animals either from birth or from 2 wk of age had a similar effect. However, if treatment was initiated at 4 wk of age, TNF delayed disease onset. These data suggest that TNF has a critical role in the early development of autoimmunity towards beta-islet cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1290746, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1307491, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1322675, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1395129, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1402671, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1409699, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1460428, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1510787, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1590993, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1594585, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1697308, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-1968489, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2107086, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2140263, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2179951, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2186750, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2194672, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2212948, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2250718, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2398274, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2405400, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2423637, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2469726, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2518361, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2540776, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2661244, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2661283, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2758698, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2794065, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2838359, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-2893286, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3055785, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3121415, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3139756, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3264405, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3282023, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3292330, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3294337, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3500186, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-3525284, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-7504266, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-7682590, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-7693764, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-7889402, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8103338, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8104408, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8171322, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8228246, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8387893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8402882, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064245-8485307
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
995-1004
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.
pubmed:affiliation
Department of Microbiology, Stanford University School of Medicine, California 94305.
More...