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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-8-18
|
| pubmed:abstractText |
The amount of human immunodeficiency virus type 1 (HIV-1) in various tissues was investigated by polymerase chain reaction (PCR) in 16 patients with end-stage HIV-1 infection and 7 patients with symptomatic but less advanced disease. During postmortem study of the 16 end-stage patients, HIV-1 DNA was found most often in lymph nodes and the spleen (both 100%), lung (93.8%), and colon (87.5%). Biopsied lymph nodes from the 7 symptomatic patients contained substantially higher copy numbers of HIV-1 RNA and DNA than did peripheral blood mononuclear cells (PBMC). Plasma viral RNA levels correlated significantly with the amount of HIV-1 RNA in PBMC (r2 = .86, P = .0025) but not with the level of viral RNA in lymph nodes in patients with symptomatic HIV-1 infection. These data suggest that although lymph nodes represent the main site for HIV-1 infection and replication, the level of circulating viral burden may not be solely determined by the magnitude of active HIV-1 replication in lymph nodes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
325-33
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8035018-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8035018-Adult,
pubmed-meshheading:8035018-Central Nervous System,
pubmed-meshheading:8035018-Child,
pubmed-meshheading:8035018-Child, Preschool,
pubmed-meshheading:8035018-Colon,
pubmed-meshheading:8035018-DNA, Viral,
pubmed-meshheading:8035018-Female,
pubmed-meshheading:8035018-Gene Expression Regulation, Viral,
pubmed-meshheading:8035018-HIV-1,
pubmed-meshheading:8035018-Humans,
pubmed-meshheading:8035018-Infant,
pubmed-meshheading:8035018-Leukocytes, Mononuclear,
pubmed-meshheading:8035018-Lung,
pubmed-meshheading:8035018-Lymph Nodes,
pubmed-meshheading:8035018-Lymphoid Tissue,
pubmed-meshheading:8035018-Male,
pubmed-meshheading:8035018-Middle Aged,
pubmed-meshheading:8035018-Polymerase Chain Reaction,
pubmed-meshheading:8035018-RNA, Messenger,
pubmed-meshheading:8035018-RNA, Viral,
pubmed-meshheading:8035018-Spleen,
pubmed-meshheading:8035018-Thymus Gland,
pubmed-meshheading:8035018-Viremia,
pubmed-meshheading:8035018-Virus Replication
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Quantitative analysis of viral burden in tissues from adults and children with symptomatic human immunodeficiency virus type 1 infection assessed by polymerase chain reaction.
|
| pubmed:affiliation |
Medicine Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
|
| pubmed:publicationType |
Journal Article
|