Linked Life Data

8014826

Source:http://linkedlifedata.com/resource/pubmed/id/8014826

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-7-28
pubmed:abstractText
We have investigated the effects of short- and long-term pinealectomy on the density of melatonin receptors in both the suprachiasmatic nuclei (SCN) and pars tuberalis (PT) of the rat. Short-term pinealectomy (conducted 3-5 days before sacrifice) induced a significant increase in the density of melatonin receptors in both structures. This increase can be interpreted as an up-regulation of melatonin receptors following the absence of plasma melatonin. In contrast, 7 days after pinealectomy, the receptor density began to decrease, reaching a low point 1.5 months after pinealectomy. At this time, the decrease represents a 40-45% reduction in binding sites as compared with values measured 3-5 days after pinealectomy. This slow decrease could be related to a slowdown of melatonin receptor synthesis. These results suggest that melatonin has a stimulatory effect on its own receptor synthesis. However, at 1.5 months after pinealectomy a novel equilibrium between synthesis and hydrolysis seems to be reached. Melatonin does not appear to be indispensable for the synthesis of its receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0742-3098
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Differential regulation of melatonin receptors by short- versus long-term pinealectomy in the rat suprachiasmatic nuclei and pars tuberalis.
pubmed:affiliation
URA-CNRS 1332, Université Louis Pasteur, Strasbourg, France.
pubmed:publicationType
Journal Article