Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-1-6
|
| pubmed:abstractText |
The c-erbB-2 protooncogene has been shown to be overexpressed and/or amplified in carcinomas of the breast, ovary, pancreas, and other organs. Several studies of human breast carcinoma noted an association of c-erbB-2 overexpression and amplification with poor prognosis. Recent studies have demonstrated c-erbB-2 protein expression in a variety of salivary gland neoplasms, most notably pleomorphic adenoma (PA), carcinoma ex pleomorphic adenoma (CAexPA), and adenocarcinoma. In this study, we analyzed c-erbB-2 expression in 15 PAs and 13 CAexPAs, using immunohistochemistry. In addition, differential polymerase chain reaction was used to evaluate c-erbB-2 gene amplification in these tumors. Low-level c-erbB-2 immunoreactivity was detected in three of 15 PAs. Among the CAexPAs, low-, intermediate-, and high-level immunoreactivity was seen in two, three, and two cases, respectively. The only cases showing c-erbB-2 amplification were the two CAexPA cases with high-level immunoreactivity. Based on statistical analysis of the 10 CAexPA patients with known outcome, no significant association of prognosis with c-erbB-2 expression or amplification was apparent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0893-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
c-erbB-2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
628-32
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:7991521-Adenoma, Pleomorphic,
pubmed-meshheading:7991521-Adult,
pubmed-meshheading:7991521-Aged,
pubmed-meshheading:7991521-Base Sequence,
pubmed-meshheading:7991521-Carcinoma,
pubmed-meshheading:7991521-DNA, Neoplasm,
pubmed-meshheading:7991521-Female,
pubmed-meshheading:7991521-Gene Expression,
pubmed-meshheading:7991521-Genes, erbB-2,
pubmed-meshheading:7991521-Humans,
pubmed-meshheading:7991521-Immunohistochemistry,
pubmed-meshheading:7991521-Male,
pubmed-meshheading:7991521-Middle Aged,
pubmed-meshheading:7991521-Molecular Sequence Data,
pubmed-meshheading:7991521-Neoplasms, Multiple Primary,
pubmed-meshheading:7991521-Polymerase Chain Reaction,
pubmed-meshheading:7991521-Prognosis,
pubmed-meshheading:7991521-Receptor, erbB-2,
pubmed-meshheading:7991521-Salivary Gland Neoplasms
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
c-erbB-2 oncoprotein expression and amplification in pleomorphic adenoma and carcinoma ex pleomorphic adenoma: relationship to prognosis.
|
| pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|