Linked Life Data

7969926

Source:http://linkedlifedata.com/resource/pubmed/id/7969926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-12-27
pubmed:abstractText
The functional roles played by metabotropic glutamate receptors in the neostriatum is just beginning to be examined. One possibility, raised by previous studies, is that metabotropic glutamate receptors act to modulate responses mediated by ionotropic glutamate receptors. In the present study, we examined this possibility in a neostriatal brain slice preparation using intracellular recording and iontophoretic techniques. We found that the iontophoretic application of the metabotropic glutamate receptor agonist 1-amino-cyclopentane-1,3-dicarboxylic acid markedly attenuated both the amplitude and duration of excitatory responses induced by the iontophoretic application of N-methyl-D-aspartate. These inhibitory effects were stereo-selective and relatively long-lasting. The metabotropic glutamate receptor antagonist 2-amino-3-phosphonopropionic acid applied either iontophoretically or in the bath prevented the inhibitory effects of 1-amino-cyclopentane-1,3-dicarboxylic acid. The inhibitory action of 1-amino-cyclopentane-1,3-dicarboxylic acid was specific to N-methyl-D-aspartate, as 1-amino-cyclopentane-1,3-dicarboxylic acid had no consistent action on the responses evoked by the iontophoretic application of glutamate, amino-3-hydroxy-5-methyl-4-isoazolepropionic acid or quisqualate. Bath application of 1-amino-cyclopentane-1,3-dicarboxylic acid inhibited the evoked depolarizing postsynaptic potentials recorded in neostriatal cells. Thus, activation of metabotropic glutamate receptors may play an important role in modulating N-methyl-D-aspartate receptor function in neostriatal neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-507
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Metabotropic glutamate receptors modulate N-methyl-D-aspartate receptor function in neostriatal neurons.
pubmed:affiliation
Mental Retardation Research Center, University of California at Los Angeles 90024-1759.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't