Linked Life Data

7954794

Source:http://linkedlifedata.com/resource/pubmed/id/7954794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-11-29
pubmed:abstractText
Mutations in the Notch (N) gene affect many processes during the development of Drosophila. Some alleles of Notch affect only particular processes, suggesting that the Notch protein (N) has more than one functional domain. We have found a series of N mutant phenotypes that are similar to those produced by the loss of function of the segment polarity gene wingless (wg) in the embryo and the adult. In addition, we observe that mutations in N behave as dominant enhancers of wg and that there exist allele-specific interactions between the two loci. Our results suggest that the product of wg is a ligand for N.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
79
pubmed:geneSymbol
N, ac, neu, wg
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-72
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Notch is required for wingless signaling in the epidermis of Drosophila.
pubmed:affiliation
Department of Zoology, University of Cambridge, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't