| pubmed-article:7943184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0023903 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0015079 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7943184 | lifeskim:mentions | umls-concept:C0064719 | lld:lifeskim |
| pubmed-article:7943184 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7943184 | pubmed:dateCreated | 1994-11-7 | lld:pubmed |
| pubmed-article:7943184 | pubmed:abstractText | We have recently demonstrated that a single injection of the mitogen lead nitrate to rats induced a rapid increase of tumor necrosis factor-alpha (TNF-alpha) mRNA in the liver and suggested that this cytokine may be involved in triggering hepatocyte proliferation in this model of direct hyperplasia. In this study, we examined whether a similar induction of liver TNF-alpha mRNA could be observed preceding the onset of hepatocyte proliferation induced by ethylene dibromide, another hepatocyte mitogen. In addition, we used dexamethasone, a well known inhibitor of TNF-alpha production, to determine whether its administration could suppress hepatocyte proliferation induced by lead nitrate and ethylene dibromide. A single intragastric administration of ethylene dibromide (100 mg/kg) to male Wistar rats enhanced liver TNF-alpha mRNA after 4 and 7 hours, which then returned to control levels by 24 hours. TNF-alpha mRNA was detectable only in a nonparenchymal cell fraction of the liver. Pretreatment of rats with a single dose of dexamethasone (2 mg/kg) 60 minutes before lead nitrate (100 mumol/kg) or ethylene dibromide completely abolished the increased levels of liver TNF-alpha mRNA induced by these agents. Inhibition by dexamethasone of TNF-alpha mRNA was associated with an inhibition of liver cell proliferation induced by these mitogens, as measured by [3H]thymidine incorporation into hepatic DNA, mitotic index, and DNA content. These results further support the hypothesis that TNF-alpha may be involved in triggering hepatocyte proliferation induced by primary mitogens. | lld:pubmed |
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| pubmed-article:7943184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7943184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7943184 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7943184 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7943184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7943184 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7943184 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:ShinozukaHH | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:KatyalS LSL | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:KuboYY | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:OkitaKK | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:ColumbanoAA | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:Ledda-Columba... | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:KayanoKK | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:CannasAA | lld:pubmed |
| pubmed-article:7943184 | pubmed:author | pubmed-author:SimbulaGG | lld:pubmed |
| pubmed-article:7943184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7943184 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:7943184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7943184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7943184 | pubmed:pagination | 951-8 | lld:pubmed |
| pubmed-article:7943184 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7943184 | pubmed:meshHeading | pubmed-meshheading:7943184-... | lld:pubmed |
| pubmed-article:7943184 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7943184 | pubmed:articleTitle | Dexamethasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth induced by lead nitrate and ethylene dibromide. | lld:pubmed |
| pubmed-article:7943184 | pubmed:affiliation | Institute of Experimental Pathology, University of Cagliari, Italy. | lld:pubmed |
| pubmed-article:7943184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7943184 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7943184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7943184 | lld:pubmed |
