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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1994-11-7
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pubmed:abstractText |
We have recently demonstrated that a single injection of the mitogen lead nitrate to rats induced a rapid increase of tumor necrosis factor-alpha (TNF-alpha) mRNA in the liver and suggested that this cytokine may be involved in triggering hepatocyte proliferation in this model of direct hyperplasia. In this study, we examined whether a similar induction of liver TNF-alpha mRNA could be observed preceding the onset of hepatocyte proliferation induced by ethylene dibromide, another hepatocyte mitogen. In addition, we used dexamethasone, a well known inhibitor of TNF-alpha production, to determine whether its administration could suppress hepatocyte proliferation induced by lead nitrate and ethylene dibromide. A single intragastric administration of ethylene dibromide (100 mg/kg) to male Wistar rats enhanced liver TNF-alpha mRNA after 4 and 7 hours, which then returned to control levels by 24 hours. TNF-alpha mRNA was detectable only in a nonparenchymal cell fraction of the liver. Pretreatment of rats with a single dose of dexamethasone (2 mg/kg) 60 minutes before lead nitrate (100 mumol/kg) or ethylene dibromide completely abolished the increased levels of liver TNF-alpha mRNA induced by these agents. Inhibition by dexamethasone of TNF-alpha mRNA was associated with an inhibition of liver cell proliferation induced by these mitogens, as measured by [3H]thymidine incorporation into hepatic DNA, mitotic index, and DNA content. These results further support the hypothesis that TNF-alpha may be involved in triggering hepatocyte proliferation induced by primary mitogens.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-13293190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1415718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1427663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1646350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1706180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1753699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-177845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1826282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1837462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1850405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-1902389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2010173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2404819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2524251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2692563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2733382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2889525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2922399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-2987855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-3008986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-3276786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-344989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-3497923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-3754653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-3910043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-4010225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-6477569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-6849373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-8041116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-8403205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-8408229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-8490557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-8514261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7943184-884515
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
951-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7943184-Animals,
pubmed-meshheading:7943184-Cell Division,
pubmed-meshheading:7943184-Dexamethasone,
pubmed-meshheading:7943184-Ethylene Dibromide,
pubmed-meshheading:7943184-Gene Expression Regulation,
pubmed-meshheading:7943184-Lead,
pubmed-meshheading:7943184-Liver,
pubmed-meshheading:7943184-Male,
pubmed-meshheading:7943184-Nitrates,
pubmed-meshheading:7943184-RNA, Messenger,
pubmed-meshheading:7943184-Rats,
pubmed-meshheading:7943184-Rats, Wistar,
pubmed-meshheading:7943184-Tumor Necrosis Factor-alpha
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pubmed:year |
1994
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pubmed:articleTitle |
Dexamethasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth induced by lead nitrate and ethylene dibromide.
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pubmed:affiliation |
Institute of Experimental Pathology, University of Cagliari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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