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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1994-10-27
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pubmed:abstractText |
Although commonly expressed human melanoma-associated antigens recognized by CD8+ cytolytic T cells have been described, little is known about CD4+ T-cell recognition of melanoma-associated antigens. Epstein-Barr virus-transformed B cells were used to present antigens derived from whole cell lysates of autologous and allogeneic melanomas for recognition by melanoma-specific CD4+ T-cell lines and clones cultured from tumor-infiltrating lymphocytes. HLA-DR-restricted antigens were detected in the lysates on the basis of specific release of cytokines from the responding T cells. Antigen sharing was demonstrated in the majority of melanomas tested, as well as in cultured normal melanocytes, but not in other normal tissues or nonmelanoma tumors. T-cell clones manifested a single recognition pattern, suggesting the presence of an immunodominant epitope. This epitope was identified as a product of the tyrosinase gene, which has also been shown to encode class I-restricted epitopes recognized by CD8+ T cells from melanoma patients. Identification of commonly expressed tumor-associated protein molecules containing epitopes presented by both class I and class II major histocompatibility molecules may provide optimal reagents for cancer immunization strategies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1568790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1720016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1729379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1835714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1840703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1868040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1918972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-1979348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2026461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2052597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2160503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2324688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2422280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2437578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2471770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2499655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2529220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2723437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2785141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-2785562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-3305708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-3422418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-3458223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-3921652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-4053039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-7516926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-7681084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-7690346,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8022805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8097319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8101473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8113668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8113684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8170938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8205528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8335937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8340755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8426105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8435428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937789-8459226
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9461-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7937789-Animals,
pubmed-meshheading:7937789-Antigens, Neoplasm,
pubmed-meshheading:7937789-B-Lymphocytes,
pubmed-meshheading:7937789-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7937789-Cell Line,
pubmed-meshheading:7937789-Cell Line, Transformed,
pubmed-meshheading:7937789-Cells, Cultured,
pubmed-meshheading:7937789-Cercopithecus aethiops,
pubmed-meshheading:7937789-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7937789-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:7937789-Herpesvirus 4, Human,
pubmed-meshheading:7937789-Humans,
pubmed-meshheading:7937789-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:7937789-Melanocytes,
pubmed-meshheading:7937789-Melanoma,
pubmed-meshheading:7937789-Melanoma-Specific Antigens,
pubmed-meshheading:7937789-Monophenol Monooxygenase,
pubmed-meshheading:7937789-Neoplasm Proteins,
pubmed-meshheading:7937789-Transfection
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pubmed:year |
1994
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pubmed:articleTitle |
Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.
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pubmed:affiliation |
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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