Linked Life Data

7924981

Source:http://linkedlifedata.com/resource/pubmed/id/7924981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-11-1
pubmed:databankReference
pubmed:abstractText
Loss-of-function mutations in Star impart a dominant rough eye phenotype and, when homozygous, are embryonic lethal with ventrolateral cuticular defects. We have cloned the Star gene and show that it encodes a novel protein with a putative transmembrane domain. Star transcript is expressed in a dynamic pattern in the embryo including in cells of the ventral midline. In the larval eye disc, Star is expressed first at the morphogenetic furrow, then in the developing R2, R5, and R8 cells as well as in the posterior clusters of the disc in additional R cells. Star interacts with Drosophila EGF receptor in the eye and mosaic analysis of Star in the larval eye disc reveals that homozygous Star patches contain no developing R cells. Taken together with the expression pattern at the morphogenetic furrow, these results demonstrate an early role for Star in photoreceptor development. Additionally, loss-of-function mutations in Star act as suppressors of R7 development in a sensitized genetic background involving the Son of sevenless (Sos) locus, and overexpression of Star enhances R7 development in this genetic background. Based on the genetic interactions with Sos, we suggest that Star also has a later role in photoreceptor development including the recruitment of the R7 cell through the sevenless pathway.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1731-45
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7924981-Amino Acid Sequence, pubmed-meshheading:7924981-Animals, pubmed-meshheading:7924981-Base Sequence, pubmed-meshheading:7924981-Drosophila Proteins, pubmed-meshheading:7924981-Drosophila melanogaster, pubmed-meshheading:7924981-Embryonic Induction, pubmed-meshheading:7924981-Eye, pubmed-meshheading:7924981-Eye Proteins, pubmed-meshheading:7924981-Genes, Insect, pubmed-meshheading:7924981-Genotype, pubmed-meshheading:7924981-Membrane Glycoproteins, pubmed-meshheading:7924981-Molecular Sequence Data, pubmed-meshheading:7924981-Phenotype, pubmed-meshheading:7924981-Photoreceptor Cells, Invertebrate, pubmed-meshheading:7924981-Receptor, Epidermal Growth Factor, pubmed-meshheading:7924981-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:7924981-Receptors, Cell Surface
pubmed:year
1994
pubmed:articleTitle
Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila.
pubmed:affiliation
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't