rdf:type |
|
lifeskim:mentions |
umls-concept:C0003323,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0332255,
umls-concept:C0332256,
umls-concept:C0444626,
umls-concept:C0521119,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
pubmed:issue |
6
|
pubmed:dateCreated |
1994-11-1
|
pubmed:abstractText |
CD4 is a transmembrane protein on the surface of T lymphocytes that interacts with MHC class II proteins at the surface of accessory cells, and is involved in the triggering of the lymphocytes by foreign antigens. It is also the major receptor for the human immunodeficiency virus. The extracellular portion of CD4 was predicted to contain four immunoglobulin superfamily domains and this has been confirmed by X-ray crystallography, but no detailed structure of domains 3 and 4 has been available.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0969-2126
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
469-81
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7922025-Amino Acid Sequence,
pubmed-meshheading:7922025-Animals,
pubmed-meshheading:7922025-Antigens, CD4,
pubmed-meshheading:7922025-Crystallography, X-Ray,
pubmed-meshheading:7922025-Glycosylation,
pubmed-meshheading:7922025-Histocompatibility Antigens Class II,
pubmed-meshheading:7922025-Models, Structural,
pubmed-meshheading:7922025-Molecular Sequence Data,
pubmed-meshheading:7922025-Molecular Structure,
pubmed-meshheading:7922025-Protein Binding,
pubmed-meshheading:7922025-Protein Conformation,
pubmed-meshheading:7922025-Rats
|
pubmed:year |
1994
|
pubmed:articleTitle |
Crystal structure of an extracellular fragment of the rat CD4 receptor containing domains 3 and 4.
|
pubmed:affiliation |
Department of Chemistry, University of York, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|