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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1994-11-10
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pubmed:abstractText |
The role of the subthalamic nucleus in the burst firing of dopamine neurones of the substantia nigra was investigated using extracellular single unit recordings combined with pressure or iontophoretic micro-injections in anaesthetized rats. Inhibition of subthalamic neurones by pressure injection of gamma-aminobutyric acid (GABA) regularized the burst firing pattern in eight out of 17 dopamine neurones. Bicuculline injection near subthalamic neurones increased their firing rate and increased burst discharge in a subpopulation of dopamine neurones tested (34 out of 102). The increase was depressed by iontophoresis of the N-methyl-D-aspartate (NMDA) antagonist (+-)2-amino,5-phosphonopentanoic acid (AP-5), but not of the non-NMDA antagonist, 6-cyano,7-nitroquinoxaline-2,3-dione (CNQX). These data suggest that the subthalamic nucleus promotes burst discharge in a subpopulation of substantia nigra dopamine neurones via NMDA receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1185-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7919161-2-Amino-5-phosphonovalerate,
pubmed-meshheading:7919161-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:7919161-Animals,
pubmed-meshheading:7919161-Bicuculline,
pubmed-meshheading:7919161-Dopamine,
pubmed-meshheading:7919161-Electrophysiology,
pubmed-meshheading:7919161-Iontophoresis,
pubmed-meshheading:7919161-Male,
pubmed-meshheading:7919161-Microinjections,
pubmed-meshheading:7919161-Neurons,
pubmed-meshheading:7919161-Rats,
pubmed-meshheading:7919161-Rats, Sprague-Dawley,
pubmed-meshheading:7919161-Receptors, Amino Acid,
pubmed-meshheading:7919161-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:7919161-Substantia Nigra,
pubmed-meshheading:7919161-Thalamic Nuclei,
pubmed-meshheading:7919161-gamma-Aminobutyric Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors.
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pubmed:affiliation |
INSERM U 171 and CNRS URA 1195, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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