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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-1-10
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pubmed:abstractText |
This study was undertaken to relate the expression of the proliferating cell nuclear antigen (PCNA), a proliferation marker of putative prognostic significance, to some more established prognostic factors in a series of 60 consecutive breast cancer surgical specimens. PCNA was detected by the PC10 monoclonal antibody (MAb) using an immunohistochemical method and PCNA immunostaining was estimated on a semiquantitative basis, a cut-off value of 50% of positively stained tumour cells discriminating between the high (> 50%) and low (< 50%) PCNA grade. The PCNA grade did not correlate with tumour size and axillary node status. However, a high PCNA grade tended to be associated with a poor histological grade and there was an inverse relationship with oestrogen-receptor status, as determined by means of the immuno-histochemical staining for the oestrogen-induced pS2 protein. These conflicting results suggest that the possible prognostic usefulness of PCNA immunostaining, as a measure of cell proliferation rate, in breast cancer is yet to be demonstrated and can be validated only by direct relation to survival data.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TFF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0960-7404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-63
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:7902763-Adenocarcinoma, Mucinous,
pubmed-meshheading:7902763-Antibodies, Monoclonal,
pubmed-meshheading:7902763-Antigens, Neoplasm,
pubmed-meshheading:7902763-Axilla,
pubmed-meshheading:7902763-Breast Neoplasms,
pubmed-meshheading:7902763-Carcinoma, Ductal, Breast,
pubmed-meshheading:7902763-Carcinoma, Lobular,
pubmed-meshheading:7902763-Carcinoma, Medullary,
pubmed-meshheading:7902763-Cell Division,
pubmed-meshheading:7902763-Estrogens,
pubmed-meshheading:7902763-Female,
pubmed-meshheading:7902763-Humans,
pubmed-meshheading:7902763-Lymphatic Metastasis,
pubmed-meshheading:7902763-Neoplasm Proteins,
pubmed-meshheading:7902763-Nuclear Proteins,
pubmed-meshheading:7902763-Prognosis,
pubmed-meshheading:7902763-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:7902763-Proteins,
pubmed-meshheading:7902763-Tumor Markers, Biological,
pubmed-meshheading:7902763-Tumor Suppressor Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Cell proliferation in breast carcinoma assessed by a PCNA grading system and its relation to other prognostic variables.
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pubmed:affiliation |
Service of Pathological Anatomy and Cytopathology, Santo Spirito Hospital, Casale Monferrato, Italy.
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pubmed:publicationType |
Journal Article
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