Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-12-23
pubmed:abstractText
The distribution of beta 1- and beta 2-adrenoceptor subtypes in mice was determined in crude membranes prepared from the submandibular gland, lung, spleen, heart and kidney, all of which are major target tissues of sympathoadrenal neurons. Scatchard analysis using [125I]-(-)iodocyanopindolol gave linear plots and the order of the density of total beta-adrenoceptors was lung > submandibular gland > spleen > kidney > heart. Competition binding studies using beta 1-selective antagonist CGP20712A indicated that all tissues examined possessed both high and low affinity sites which approximately stand for beta 1- and beta 2-adrenoceptor subtypes respectively despite the notable difference in the ratios of high and low affinity sites depending on the tissues. The order of the occupancy of high affinity sites was submandibular gland (71%), heart (55%), spleen (18%), kidney (17%), lung (14%). These results will be helpful to elucidate the regulatory mechanism which underlies beta-adrenergic functions in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-100
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Distribution of beta 1- and beta 2-adrenoceptor subtypes in various mouse tissues.
pubmed:affiliation
Joint Research Division for Therapies against Intractable Diseases, School of Medicine, Fujita Health University, Aichi, Japan.
pubmed:publicationType
Journal Article, In Vitro