Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-3-20
pubmed:databankReference
pubmed:abstractText
The phyllopod (phyl) gene regulates the fates of a subset of cells in the developing Drosophila eye; in the absence of phyl function, the R1, R6, and R7 photoreceptors are transformed into additional cone cells, whereas ectopic phyl expression in the cone cell precursors transforms these cells into additional R7 cells. Within this group of cells, phyl expression thus mimics activation of the Raf pathway in its ability to induce photoreceptor rather than cone cell development. Furthermore, the transformation of cone cells into R7 cells in response to Raf activation is both accompanied by and dependent upon ectopic phyl expression. phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
453-62
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7859287-Amino Acid Sequence, pubmed-meshheading:7859287-Animals, pubmed-meshheading:7859287-Cell Differentiation, pubmed-meshheading:7859287-Cloning, Molecular, pubmed-meshheading:7859287-Crosses, Genetic, pubmed-meshheading:7859287-Drosophila, pubmed-meshheading:7859287-Drosophila Proteins, pubmed-meshheading:7859287-Eye, pubmed-meshheading:7859287-Gene Dosage, pubmed-meshheading:7859287-Gene Expression Regulation, Developmental, pubmed-meshheading:7859287-Genes, Insect, pubmed-meshheading:7859287-Larva, pubmed-meshheading:7859287-Molecular Sequence Data, pubmed-meshheading:7859287-Nuclear Proteins, pubmed-meshheading:7859287-Photoreceptor Cells, Invertebrate, pubmed-meshheading:7859287-Protein-Serine-Threonine Kinases, pubmed-meshheading:7859287-Proto-Oncogene Proteins, pubmed-meshheading:7859287-Proto-Oncogene Proteins c-raf, pubmed-meshheading:7859287-RNA, Messenger, pubmed-meshheading:7859287-Sequence Analysis, DNA, pubmed-meshheading:7859287-Suppression, Genetic
pubmed:year
1995
pubmed:articleTitle
Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase.
pubmed:affiliation
Zoologisches Institut, Universität Zürich, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't