| pubmed-article:7858059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0600251 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7858059 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:7858059 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7858059 | pubmed:dateCreated | 1995-3-22 | lld:pubmed |
| pubmed-article:7858059 | pubmed:abstractText | Heat treatments administered prior to the onset of sepsis or endotoxemia markedly increase survival. A potential mechanism for the beneficial effect of heat could be effects on IL-1 alpha and TNF-alpha, important mediators of sepsis and endotoxemia. Administration of IL-1 or TNF prior to development of sepsis and endotoxemia increases survival; thus, prophylactic heat treatments may protect by releasing IL-1 or TNF. Paradoxically, an alternative mechanism of protection of prophylactic heat treatments could be to decrease the amount of IL-1 and TNF released during sepsis or endotoxemia. Cells pretreated with heat do not produce as much IL-1 or TNF in response to endotoxin as cells that have not been pretreated with heat. The purpose of this investigation was to determine if hyperthermia caused release of cytokines and/or blunted the rise in cytokines occurring after endotoxin. Mice were anesthetized with ketamine/xylazine and immersed in a water bath at 37.0 or 42.0 degrees C for sham or heat treatments. At 6-7 h after recovery from anesthesia and immersion, sham and heat-treated mice were injected with Escherichia coli endotoxin. Both heat-treated and sham mice had elevated plasma IL-1 alpha 2 h after anesthesia and immersion but IL-1 alpha was approximately 3-fold greater in the heated mice, 732 +/- 50 vs. 256 +/- 76 pg/ml (p < 0.01). Blood samples obtained after endotoxin revealed no difference in levels of TNF-alpha (5477 +/- 742 vs. 6514 +/- 652 pg/ml) or IL-1 alpha (546 +/- 72 vs. 603 +/- 121 pg/ml) in the sham vs. heated mice.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7858059 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7858059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7858059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7858059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7858059 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7858059 | pubmed:issn | 1056-5477 | lld:pubmed |
| pubmed-article:7858059 | pubmed:author | pubmed-author:KarpMM | lld:pubmed |
| pubmed-article:7858059 | pubmed:author | pubmed-author:BlakeDD | lld:pubmed |
| pubmed-article:7858059 | pubmed:author | pubmed-author:BesserWW | lld:pubmed |
| pubmed-article:7858059 | pubmed:author | pubmed-author:HotchkissRR | lld:pubmed |
| pubmed-article:7858059 | pubmed:author | pubmed-author:NunnallyII | lld:pubmed |
| pubmed-article:7858059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7858059 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:7858059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7858059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7858059 | pubmed:pagination | 271-5 | lld:pubmed |
| pubmed-article:7858059 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:meshHeading | pubmed-meshheading:7858059-... | lld:pubmed |
| pubmed-article:7858059 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7858059 | pubmed:articleTitle | Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin. | lld:pubmed |
| pubmed-article:7858059 | pubmed:affiliation | Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
| pubmed-article:7858059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7858059 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7858059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7858059 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7858059 | lld:pubmed |
