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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0004112,
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0021745,
umls-concept:C0024518,
umls-concept:C0063695,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0330390,
umls-concept:C0443199,
umls-concept:C0521457,
umls-concept:C1280500,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
1995-3-10
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pubmed:abstractText |
We investigated the modulatory effects of human interferon beta (IFN-beta) and gamma (IFN-gamma) on expression of class I and II major histocompatibility complex (MHC) antigens and intercellular adhesion molecule-1 (ICAM-1) in fetal human astrocytes in culture using flow cytometry and immunocytochemistry. Under the baseline condition, class I MHC antigen and ICAM-1 were expressed in a moderate number (23 to 76%) of astrocytes, whereas class II MHC antigen was expressed in only a small number (0.3 to 8%) of astrocytes. Following a 72-hour treatment with IFN-gamma (10 to 100 U/ml), expression of all three antigens increased greatly. Expression of class I MHC antigen was also elevated by exposure to IFN-beta (10 and 100 IU/ml). However, IFN-beta did not significantly induce expression of class II MHC antigen or ICAM-1. Furthermore, IFN-beta significantly reduced IFN-gamma-induced expression of class II MHC antigen but not of class I MHC antigen or of ICAM-1. The differential effects of IFN-beta and IFN-gamma on expression of class I and II MHC antigens and ICAM-1 in fetal human astrocytes suggest that interferons serve as modulators of astrocyte function at sites of inflammation in the human CNS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-3878
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-73
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7854540-Abortion, Legal,
pubmed-meshheading:7854540-Abortion, Therapeutic,
pubmed-meshheading:7854540-Astrocytes,
pubmed-meshheading:7854540-Brain,
pubmed-meshheading:7854540-Cells, Cultured,
pubmed-meshheading:7854540-Dose-Response Relationship, Drug,
pubmed-meshheading:7854540-Female,
pubmed-meshheading:7854540-Fetus,
pubmed-meshheading:7854540-Gestational Age,
pubmed-meshheading:7854540-Glial Fibrillary Acidic Protein,
pubmed-meshheading:7854540-HLA-D Antigens,
pubmed-meshheading:7854540-Histocompatibility Antigens Class I,
pubmed-meshheading:7854540-Humans,
pubmed-meshheading:7854540-Immunohistochemistry,
pubmed-meshheading:7854540-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7854540-Interferon-beta,
pubmed-meshheading:7854540-Interferon-gamma,
pubmed-meshheading:7854540-Major Histocompatibility Complex,
pubmed-meshheading:7854540-Pregnancy,
pubmed-meshheading:7854540-Recombinant Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular adhesion molecule-1 in cultured fetal human astrocytes.
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pubmed:affiliation |
Department of Medicine, University of British Columbia, Vancouver, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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