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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1995-3-10
|
| pubmed:abstractText |
The effect of zinc deficiency on the levels of n-6 and n-3 polyunsaturated fatty acids (PUFA) in lipids from tissues of rats fed a diet containing linseed oil was investigated. Rats were fed either a control diet (25 mg Zn/kg) or a zinc-deficient diet (0.8 mg Zn/kg) for 10 d. To avoid energy and nutrient deficiency, 11.6 g of diet per day was administered by gastric tube. At the end of the experiment, rats fed the zinc-deficient diet had drastically reduced plasma zinc concentration and alkaline phosphatase activity consistent with severe zinc deficiency in these rats. Zinc-deficient rats had higher levels of n-3 PUFA, in particular eicosapentaenoic acid (EPA), and lower levels of n-6 PUFA, in particular linoleic acid, in liver and plasma phosphatidylcholine (PC) and in erythrocyte membrane total lipids than did control rats. By contrast, the levels of n-3 PUFA in PC from testes and heart, and in phosphatidylethanolamine (PE) from liver, testes and heart, were only slightly different between zinc-deficient and control rats. The study suggests that desaturation of alpha-linolenic acid is not inhibited by zinc deficiency, and that in zinc-deficient rats, n-3 PUFA preferentially incorporated into phospholipids at the expense of n-6 PUFA, especially EPA into PC. The study also shows that the effect of zinc deficiency on PUFA levels is different for PC and PE in rat tissues.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0024-4201
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
839-44
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7854009-Animals,
pubmed-meshheading:7854009-Dietary Fats, Unsaturated,
pubmed-meshheading:7854009-Fatty Acids, Unsaturated,
pubmed-meshheading:7854009-Linseed Oil,
pubmed-meshheading:7854009-Lipid Metabolism,
pubmed-meshheading:7854009-Liver,
pubmed-meshheading:7854009-Male,
pubmed-meshheading:7854009-Rats,
pubmed-meshheading:7854009-Rats, Sprague-Dawley,
pubmed-meshheading:7854009-Zinc
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Levels of polyunsaturated fatty acids in tissues from zinc-deficient rats fed a linseed oil diet.
|
| pubmed:affiliation |
Institut für Ernährungsphysiologie, Technische Universität München, Freising, Germany.
|
| pubmed:publicationType |
Journal Article
|