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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-3-3
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pubmed:abstractText |
Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-Stimulated Gene Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-Stimulated Gene Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Isgf3g protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
358
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7843405-Amino Acid Sequence,
pubmed-meshheading:7843405-Animals,
pubmed-meshheading:7843405-Base Sequence,
pubmed-meshheading:7843405-Cells, Cultured,
pubmed-meshheading:7843405-DNA-Binding Proteins,
pubmed-meshheading:7843405-Gene Expression Regulation, Viral,
pubmed-meshheading:7843405-HeLa Cells,
pubmed-meshheading:7843405-Humans,
pubmed-meshheading:7843405-Interferon-Stimulated Gene Factor 3,
pubmed-meshheading:7843405-Interferon-Stimulated Gene Factor 3, gamma Subunit,
pubmed-meshheading:7843405-Interferon-beta,
pubmed-meshheading:7843405-Mice,
pubmed-meshheading:7843405-Molecular Sequence Data,
pubmed-meshheading:7843405-Newcastle disease virus,
pubmed-meshheading:7843405-RNA, Messenger,
pubmed-meshheading:7843405-Sequence Homology, Amino Acid,
pubmed-meshheading:7843405-Transcription Factors,
pubmed-meshheading:7843405-Transcriptional Activation
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pubmed:year |
1995
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pubmed:articleTitle |
Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.
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pubmed:affiliation |
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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