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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1995-2-22
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pubmed:abstractText |
The non-competitive N-methyl-D-aspartate (NMDA) antagonist, ifenprodil, discriminates two receptor populations, each of which shows a reciprocal abundance in cultured cortical and cerebellar granule cells. Thus approximately 70% of NMDA-gated membrane current was antagonized with high affinity (IC50 = 1.4 +/- 0.9 microM) in cortical neurones whereas only approximately 20% was antagonized with high affinity (IC50 = 1.3 +/- 0.3 microM) in granule cells. Inhibition curves for CGS 19755 appeared relatively monophasic: this competitive NMDA antagonist had a significantly higher affinity for the granule cell receptor (Ki = 0.8 +/- 0.2 microM) compared with that on cortical neurones (Ki = 2 +/- 0.6 microM). The data suggest that these two antagonists may be of value in identifying the expression of subpopulations of native NMDA receptors in other brain regions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1763-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7827326-Animals,
pubmed-meshheading:7827326-Brain,
pubmed-meshheading:7827326-Brain Chemistry,
pubmed-meshheading:7827326-Cells, Cultured,
pubmed-meshheading:7827326-Glycine,
pubmed-meshheading:7827326-N-Methylaspartate,
pubmed-meshheading:7827326-Neurons,
pubmed-meshheading:7827326-Patch-Clamp Techniques,
pubmed-meshheading:7827326-Pipecolic Acids,
pubmed-meshheading:7827326-Piperidines,
pubmed-meshheading:7827326-Rats,
pubmed-meshheading:7827326-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1994
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pubmed:articleTitle |
Subtypes of NMDA receptor in neurones cultured from rat brain.
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pubmed:affiliation |
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
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pubmed:publicationType |
Journal Article
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