| pubmed-article:7815373 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7815373 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7815373 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7815373 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:7815373 | lifeskim:mentions | umls-concept:C0031090 | lld:lifeskim |
| pubmed-article:7815373 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7815373 | pubmed:dateCreated | 1995-2-9 | lld:pubmed |
| pubmed-article:7815373 | pubmed:abstractText | IL-4- and IL-6-producing cells in human periodontal disease tissues were investigated using immunohistochemical and in situ hybridization techniques. Immunohistochemical analysis demonstrated the presence of IL-4-producing cells within the CD45RO+ subset and the percentage of IL-4+ cells was significantly higher in periodontal lesions than in gingivitis tissues (p < 0.01). The percentage of IL-6-producing memory cells was higher in periodontal lesions compared with gingivitis tissues, although it was not statistically significant (p > 0.05). A reverse tendency in IL-4- and IL-6-positive cells was observed in a few individual cases. No IL-4 mRNA could be detected using the in situ hybridization technique. However, high levels of IL-6 mRNA were present in clinically healthy tissues, with a further increase in both epithelium and connective tissues affected by gingivitis, although only the former was significant (p < 0.025). There was a significant decrease in IL-6 mRNA in both the connective tissue (p < 0.025) and epithelium (p < 0.01) in periodontitis tissues compared with levels in gingivitis tissues. However, the levels of IL-6 mRNA in periodontal tissues were high compared with those of IL-1 mRNA, which was used in this study as a positive control. These results suggest that Th2-type cells may accumulate in periodontal lesions. | lld:pubmed |
| pubmed-article:7815373 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7815373 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7815373 | pubmed:citationSubset | D | lld:pubmed |
| pubmed-article:7815373 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7815373 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7815373 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7815373 | pubmed:issn | 0904-2512 | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:HaraKK | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:NakajimaTT | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:YamazakiKK | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:SeymourG JGJ | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:PolakBB | lld:pubmed |
| pubmed-article:7815373 | pubmed:author | pubmed-author:GemmellEE | lld:pubmed |
| pubmed-article:7815373 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7815373 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7815373 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7815373 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7815373 | pubmed:pagination | 347-53 | lld:pubmed |
| pubmed-article:7815373 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7815373 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7815373 | pubmed:articleTitle | IL-4- and IL-6-producing cells in human periodontal disease tissue. | lld:pubmed |
| pubmed-article:7815373 | pubmed:affiliation | Department of Periodontology, Niigata University School of Dentistry, Japan. | lld:pubmed |
| pubmed-article:7815373 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7815373 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7815373 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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