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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1995-2-9
|
| pubmed:abstractText |
IL-4- and IL-6-producing cells in human periodontal disease tissues were investigated using immunohistochemical and in situ hybridization techniques. Immunohistochemical analysis demonstrated the presence of IL-4-producing cells within the CD45RO+ subset and the percentage of IL-4+ cells was significantly higher in periodontal lesions than in gingivitis tissues (p < 0.01). The percentage of IL-6-producing memory cells was higher in periodontal lesions compared with gingivitis tissues, although it was not statistically significant (p > 0.05). A reverse tendency in IL-4- and IL-6-positive cells was observed in a few individual cases. No IL-4 mRNA could be detected using the in situ hybridization technique. However, high levels of IL-6 mRNA were present in clinically healthy tissues, with a further increase in both epithelium and connective tissues affected by gingivitis, although only the former was significant (p < 0.025). There was a significant decrease in IL-6 mRNA in both the connective tissue (p < 0.025) and epithelium (p < 0.01) in periodontitis tissues compared with levels in gingivitis tissues. However, the levels of IL-6 mRNA in periodontal tissues were high compared with those of IL-1 mRNA, which was used in this study as a positive control. These results suggest that Th2-type cells may accumulate in periodontal lesions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0904-2512
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
347-53
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7815373-Adult,
pubmed-meshheading:7815373-Autoradiography,
pubmed-meshheading:7815373-Connective Tissue,
pubmed-meshheading:7815373-Epithelium,
pubmed-meshheading:7815373-Fibroblasts,
pubmed-meshheading:7815373-Gingiva,
pubmed-meshheading:7815373-Gingivitis,
pubmed-meshheading:7815373-Humans,
pubmed-meshheading:7815373-Immunohistochemistry,
pubmed-meshheading:7815373-Immunologic Memory,
pubmed-meshheading:7815373-In Situ Hybridization,
pubmed-meshheading:7815373-Interleukin-4,
pubmed-meshheading:7815373-Interleukin-6,
pubmed-meshheading:7815373-Leukocytes, Mononuclear,
pubmed-meshheading:7815373-Middle Aged,
pubmed-meshheading:7815373-Periodontitis,
pubmed-meshheading:7815373-Periodontium,
pubmed-meshheading:7815373-RNA, Messenger,
pubmed-meshheading:7815373-T-Lymphocyte Subsets
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
IL-4- and IL-6-producing cells in human periodontal disease tissue.
|
| pubmed:affiliation |
Department of Periodontology, Niigata University School of Dentistry, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|