Linked Life Data

7810274

Source:http://linkedlifedata.com/resource/pubmed/id/7810274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1995-2-2
pubmed:abstractText
Acute alcoholic hepatitis is accompanied by features of the acute phase response, peripheral blood neutrophilia and liver neutrophil infiltrate even in the absence of demonstrable bacterial or fungal infection. Plasma levels of tumour necrosis factor (TNF) and interleukin-6 (IL-6), the major cytokine inducers of the acute phase response, are markedly raised in acute alcoholic hepatitis and correlate closely with clinical and laboratory indicators of disease severity. The potent neutrophil activator and chemotaxin interleukin-8 (IL-8) is released in response to TNF and recent interest has focussed on its possible role in producing the characteristic peripheral blood neutrophilia and liver neutrophil infiltrate in alcoholic hepatitis. Circulating IL-8 and liver tissue levels of IL-8 are markedly raised in alcoholic hepatitis, with highest levels in patients who die within the first four weeks of admission to hospital. There is a close correlation between hepatic IL-8 and infiltration with neutrophils. Less dramatic increases in circulating IL-8 are present in abstinent alcoholic cirrhotics and patients admitted for detoxification. These observations suggest a central role for IL-8 in the neutrophilia and hepatic neutrophil infiltrate characteristic of acute alcoholic hepatitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5644
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Interleukin-8 in alcoholic liver disease.
pubmed:affiliation
Department of Gastroenterology, Gartnavel General Hospital, Glasgow.
pubmed:publicationType
Journal Article, Review