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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-8-3
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pubmed:abstractText |
The cytokine tumor necrosis factor alpha (TNF-alpha) is a primary inflammatory mediator after liver injury. Several cytokines impair the regulation of cytochrome P450 (CYP) genes in liver, but the specificity of these effects remains unclear. This study investigated the effects of recombinant murine TNF-alpha on the expression of specific constitutive CYPs in male rat liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2E1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid 16-alpha-Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-205
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7797018-Analysis of Variance,
pubmed-meshheading:7797018-Animals,
pubmed-meshheading:7797018-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:7797018-Biotransformation,
pubmed-meshheading:7797018-Cytochrome P-450 CYP2E1,
pubmed-meshheading:7797018-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7797018-Down-Regulation,
pubmed-meshheading:7797018-Estradiol,
pubmed-meshheading:7797018-Hydroxylation,
pubmed-meshheading:7797018-Liver,
pubmed-meshheading:7797018-Male,
pubmed-meshheading:7797018-Microsomes, Liver,
pubmed-meshheading:7797018-Mixed Function Oxygenases,
pubmed-meshheading:7797018-Progesterone,
pubmed-meshheading:7797018-Protein Biosynthesis,
pubmed-meshheading:7797018-RNA, Messenger,
pubmed-meshheading:7797018-Rats,
pubmed-meshheading:7797018-Recombinant Proteins,
pubmed-meshheading:7797018-Steroid 16-alpha-Hydroxylase,
pubmed-meshheading:7797018-Steroid Hydroxylases,
pubmed-meshheading:7797018-Testosterone,
pubmed-meshheading:7797018-Thyroxine,
pubmed-meshheading:7797018-Triiodothyronine,
pubmed-meshheading:7797018-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha.
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pubmed:affiliation |
Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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