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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
1995-6-20
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pubmed:abstractText |
A previous report of a large, double blind, efficacy trial of an experimental Group B meningococcal outer membrane protein vaccine carried out in Norwegian Teenagers, showed a protection rate of 57%. Previous studies had demonstrated the occurrence of mutations in the class-1 outer membrane protein which alter its immunological properties. The occurrence of new mutations might compromise the efficacy of a vaccine and explain the occurrence of any vaccine failures. The porA gene, which encodes expression of the class 1 protein, was sequenced in all isolates from vaccine failures and compared to that of the vaccinating strain H44/76 (B:15:P1.7,16). The porA DNA and deduced amino acid sequences were all identical to that of the vaccinating strain except for that of one isolate which had a sequence identical to strains previously reported in Norway and England with a 'masked P1.7' epitope. The absence of new mutations in the trial was encouraging for the further development of outer membrane protein vaccines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0882-4010
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-30
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pubmed:dateRevised |
2011-4-7
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pubmed:meshHeading |
pubmed-meshheading:7752883-Adolescent,
pubmed-meshheading:7752883-Amino Acid Sequence,
pubmed-meshheading:7752883-Bacterial Capsules,
pubmed-meshheading:7752883-Bacterial Vaccines,
pubmed-meshheading:7752883-DNA, Bacterial,
pubmed-meshheading:7752883-Female,
pubmed-meshheading:7752883-Gene Expression Regulation, Bacterial,
pubmed-meshheading:7752883-Humans,
pubmed-meshheading:7752883-Immunotherapy, Active,
pubmed-meshheading:7752883-Male,
pubmed-meshheading:7752883-Meningococcal Infections,
pubmed-meshheading:7752883-Molecular Sequence Data,
pubmed-meshheading:7752883-Mutation,
pubmed-meshheading:7752883-Neisseria meningitidis,
pubmed-meshheading:7752883-Norway,
pubmed-meshheading:7752883-Polysaccharides, Bacterial,
pubmed-meshheading:7752883-Porins,
pubmed-meshheading:7752883-Treatment Failure
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pubmed:year |
1994
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pubmed:articleTitle |
Comparison of the class-1 outer membrane protein from B:15:P1.16 Neisseria meningitidis strains isolated from patients previously immunized with a serogroup B outer membrane protein vaccine in Norway.
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pubmed:affiliation |
University of Southampton Medical School, Southampton General Hospital, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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