|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017932,
umls-concept:C0021641,
umls-concept:C0033634,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0044602,
umls-concept:C0078517,
umls-concept:C0206131,
umls-concept:C0752312,
umls-concept:C1705535,
umls-concept:C1707455,
umls-concept:C1709060,
umls-concept:C1879547,
umls-concept:C2603343
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1995-5-30
|
|
pubmed:abstractText |
Wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked insulin-induced activation of glycogen synthase (GS) and mitogen-activated protein kinase (MAPK) in rat adipocytes. These inhibitions were relatively specific, as wortmannin did not block GS activation by a protein kinase C (PKC) inhibitor, or MAPK activation by phorbol esters. Our findings suggest that PI3K is required for the activation of both GS and MAPK in rat adipocytes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
209
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1082-8
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:7733962-Adipocytes,
pubmed-meshheading:7733962-Androstadienes,
pubmed-meshheading:7733962-Animals,
pubmed-meshheading:7733962-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:7733962-Cells, Cultured,
pubmed-meshheading:7733962-Deoxyglucose,
pubmed-meshheading:7733962-Enzyme Activation,
pubmed-meshheading:7733962-Enzyme Inhibitors,
pubmed-meshheading:7733962-Epididymis,
pubmed-meshheading:7733962-Glycogen Synthase,
pubmed-meshheading:7733962-Insulin,
pubmed-meshheading:7733962-Kinetics,
pubmed-meshheading:7733962-Male,
pubmed-meshheading:7733962-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:7733962-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:7733962-Protein Kinase C,
pubmed-meshheading:7733962-Rats,
pubmed-meshheading:7733962-Tetradecanoylphorbol Acetate
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators.
|
|
pubmed:affiliation |
J.A. Haley Veterans' Hospital, Department of Internal Medicine, University of South Florida College of Medicine, University of South Florida, Tampa 33612, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
