Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-23
pubmed:abstractText
Patients with fractures of the zygomatic bone were treated with high molecular weight poly(L-lactic) acid (PLLA) bone plates and screws. Three years after implantation four patients returned to our department with a swelling at the site of implantation. At the recall of the remaining patients we found an identical type of swelling after the same implantation period. To investigate the nature of the tissue reaction, eight patients were reoperated for the removal of the swelling. The implantation period of the PLLA material varied from 3.3 to 5.7 years. Microscopic evaluation and molecular weight measurements were performed. The excised material showed remnants of degraded PLLA material surrounded by a dense fibrous capsule. Ultrastructural investigation showed crystal-like PLLA material internalized by various cells. The results of this investigation suggest that the PLLA material slowly degrades into particles with a high crystallinity. The intra- and extracellular degradation rate of these particles is very low. After 5.7 years of implantation, these particles were still not fully resorbed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7718688-Acid Phosphatase, pubmed-meshheading:7718688-Adult, pubmed-meshheading:7718688-Alkaline Phosphatase, pubmed-meshheading:7718688-Biodegradation, Environmental, pubmed-meshheading:7718688-Bone Plates, pubmed-meshheading:7718688-Bone Screws, pubmed-meshheading:7718688-Collagen, pubmed-meshheading:7718688-Enzyme Activation, pubmed-meshheading:7718688-Humans, pubmed-meshheading:7718688-L-Lactate Dehydrogenase, pubmed-meshheading:7718688-Lactates, pubmed-meshheading:7718688-Lactic Acid, pubmed-meshheading:7718688-Longitudinal Studies, pubmed-meshheading:7718688-Lysosomes, pubmed-meshheading:7718688-Microscopy, Electron, pubmed-meshheading:7718688-Microscopy, Electron, Scanning, pubmed-meshheading:7718688-Middle Aged, pubmed-meshheading:7718688-Mitochondria, pubmed-meshheading:7718688-Mitochondrial Swelling, pubmed-meshheading:7718688-Molecular Weight, pubmed-meshheading:7718688-Phagosomes, pubmed-meshheading:7718688-Polymers, pubmed-meshheading:7718688-Reoperation, pubmed-meshheading:7718688-Substrate Specificity, pubmed-meshheading:7718688-Zygomatic Fractures
pubmed:year
1995
pubmed:articleTitle
Late degradation tissue response to poly(L-lactide) bone plates and screws.
pubmed:affiliation
Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands.
pubmed:publicationType
Journal Article