| pubmed-article:7707521 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C0206435 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C1167298 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7707521 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:7707521 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7707521 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7707521 | pubmed:abstractText | To identify proteins involved in the formation of replication complexes at the 3' end of poliovirus negative-strand RNA, a combined in vitro biochemical and in vivo genetic approach was used. Five subgenomic cDNA constructs were generated to transcribe different negative-strand RNA fragments. In UV cross-linking assays, distinct differences in binding of proteins in extracts from poliovirus-infected and uninfected cells to virus-specific, radiolabeled transcripts were observed. Two proteins present in extracts from poliovirus-infected cells with approximate molecular masses of 36 and 38 kDa were shown to cross-link to the 3' end of poliovirus negative-strand RNA. Appearance of the 36- and 38-kDa proteins in UV cross-linking assays can be detected 3 to 3.5 h after infection, and cross-linking reaches maximum levels by 5 h after infection. The binding site for the 36-kDa protein overlaps with the computer-predicted loop b region of stem-loop I, the so-called cloverleaf structure, and the RNA sequence of this region is required for efficient binding. Transfection of full-length, positive-sense RNA containing a five-nucleotide substitution (positions 20 to 25) in the loop b region of stem-loop I into tissue culture cells yielded only viral isolates with a reversion at position 24 (U-->C). This finding demonstrates that the wild-type cytidine residue at position 24 is essential for virus replication. RNA binding studies with transcripts corresponding to the 3' end of negative-strand RNA suggest that complex formation with the 36-kDa protein plays an essential role during the viral life cycle. | lld:pubmed |
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| pubmed-article:7707521 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7707521 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7707521 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7707521 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7707521 | pubmed:month | May | lld:pubmed |
| pubmed-article:7707521 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:7707521 | pubmed:author | pubmed-author:SemlerB LBL | lld:pubmed |
| pubmed-article:7707521 | pubmed:author | pubmed-author:RoehlH HHH | lld:pubmed |
| pubmed-article:7707521 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7707521 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:7707521 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7707521 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7707521 | pubmed:pagination | 2954-61 | lld:pubmed |
| pubmed-article:7707521 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7707521 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7707521 | pubmed:articleTitle | Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA. | lld:pubmed |
| pubmed-article:7707521 | pubmed:affiliation | Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine 92717, USA. | lld:pubmed |
| pubmed-article:7707521 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7707521 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7707521 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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