Linked Life Data

7700956

Source:http://linkedlifedata.com/resource/pubmed/id/7700956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-4
pubmed:abstractText
The effect of aging on three different parameters possibly relevant for cognition was investigated in female Naval Medical Research Institute mice: a) N-methyl-D-aspartate (NMDA) receptor density, as determined by the specific binding of [3H]MK-801 to forebrain membranes, decreased by 22% in aged (23 mo) and by 19% in middle-aged (12 mo) animals compared with young (3 mo) animals. b) In a passive avoidance acquisition task, the 24-h latency decreased significantly with age; the middle-aged mice also tended to show impairment in this task. c) The fluidity of the forebrain membranes also decreased significantly with age. Again, there was a significant reduction in the middle-aged group. A comparison of these parameters revealed significant correlations between NMDA receptor density and 24-h latency (r = 0.52, p < 0.003) over all three age groups, as well as significant correlations between membrane fluidity and either NMDA receptor density or 24-h latency. These findings do not prove a causal relationship, but are compatible with the hypothesis that changes of membrane fluidity, by decreasing the number of NMDA receptors, affect passive avoidance performance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
N-methyl-D-aspartate receptor density and membrane fluidity as possible determinants of the decline of passive avoidance performance in aging.
pubmed:affiliation
Central Institute for Mental Health, Department of Psychopharmacology, Mannheim, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't