Linked Life Data

7697373

Source:http://linkedlifedata.com/resource/pubmed/id/7697373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-5-3
pubmed:abstractText
We examined effects of interleukin 1 alpha (IL-1 alpha) on prostaglandin production in piglet cultured astroglia. Immuno- and morphologically identified polymorphic and process-bearing astrocytes were collected from cerebral cortex and white matter from piglets (1-3 days of age). Levels of prostaglandins were determined using enzyme immunoassay. Baseline levels for prostaglandin (PG) F2 alpha were 631 +/- 332 pg/ml and increased to 1417 +/- 353 pg/ml 20 min after addition of 11 micrograms/ml IL-1 alpha (p < 0.05) and to 2280 +/- 391 pg/ml 20 min after addition of 22 micrograms/ml IL-1 alpha (p < 0.05) (n = 7). Only small amounts of 6-keto-PGF 1 alpha or PGE2 were detected in medium under baseline conditions or in the presence of IL-1 alpha. Medium alone did not change PGF2 alpha levels (n = 3). Coapplication of cycloheximide (10(-3) M) blocked the increase in PGF2 alpha (n = 3). We conclude that IL-1 alpha causes a rapid increase in prostaglandin production by astroglia, and this process involves a step requiring continued or increased protein synthesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin 1 alpha.
pubmed:affiliation
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1083.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't