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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5135
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pubmed:dateCreated |
1993-12-8
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pubmed:abstractText |
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is the predominant ligand for the T cell-activation molecule CTLA-4. GL1 provides a critical signal for T cell-dependent responses in vitro and in vivo.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
905-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7694361-Animals,
pubmed-meshheading:7694361-Antibodies, Monoclonal,
pubmed-meshheading:7694361-Antigens, CD,
pubmed-meshheading:7694361-Antigens, CD18,
pubmed-meshheading:7694361-Antigens, CD80,
pubmed-meshheading:7694361-Antigens, Differentiation,
pubmed-meshheading:7694361-Antigens, Surface,
pubmed-meshheading:7694361-B-Lymphocytes,
pubmed-meshheading:7694361-CHO Cells,
pubmed-meshheading:7694361-CTLA-4 Antigen,
pubmed-meshheading:7694361-Cricetinae,
pubmed-meshheading:7694361-Immunoconjugates,
pubmed-meshheading:7694361-Interleukin-2,
pubmed-meshheading:7694361-Lymphocyte Activation,
pubmed-meshheading:7694361-Mice,
pubmed-meshheading:7694361-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.
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pubmed:affiliation |
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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