Linked Life Data

7686692

Source:http://linkedlifedata.com/resource/pubmed/id/7686692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-8-5
pubmed:abstractText
Activation and inactivation of protein C during the clinical course of disseminated intravascular coagulation (DIC) was studied in three patients by qualitative (Western blotting) and quantitative (ELISA) analysis and the intensity of procoagulant activity monitored by the measurement of thrombin and factor Xa antithrombin III complexes. In one patient, inhibitor complexes of APC with protein C inhibitor (PCI) and alpha 1-antitrypsin (alpha 1-AT) were observed and the latter predominated at presentation. Both disappeared during the development of remission but the loss of alpha 1-AT complexes preceded PCI complexes which on Western blotting appeared to increase in intensity prior to disappearance. The two other patients bled to death from uncontrollable haemorrhage. In both cases, APC/inhibitor complexes with alpha 2-macroglobulin (alpha 2-M) in addition to PCI and alpha 1-AT were detected and persisted until death. Although PCI appeared to be the primary inhibitor in all three cases, alpha 1-antitrypsin and particularly alpha 2-macroglobulin appeared to assume greater roles in the two fatal cases. These data are similar to previous findings in an experimental animal model of DIC that suggested that alpha 2-macroglobulin and alpha 1-antitrypsin become more important inhibitors of APC as the primary inhibitor PCI is consumed in the face of a sustained procoagulant challenge.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0340-6245
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7686692-Adult, pubmed-meshheading:7686692-Antithrombin III, pubmed-meshheading:7686692-Blood Coagulation Tests, pubmed-meshheading:7686692-Cerebral Hemorrhage, pubmed-meshheading:7686692-Disseminated Intravascular Coagulation, pubmed-meshheading:7686692-Enzyme Activation, pubmed-meshheading:7686692-Female, pubmed-meshheading:7686692-Humans, pubmed-meshheading:7686692-Male, pubmed-meshheading:7686692-Middle Aged, pubmed-meshheading:7686692-Peptide Hydrolases, pubmed-meshheading:7686692-Plasminogen Inactivators, pubmed-meshheading:7686692-Postoperative Complications, pubmed-meshheading:7686692-Protein C, pubmed-meshheading:7686692-Protein C Inhibitor, pubmed-meshheading:7686692-Puerperal Disorders, pubmed-meshheading:7686692-alpha 1-Antitrypsin, pubmed-meshheading:7686692-alpha-Macroglobulins
pubmed:year
1993
pubmed:articleTitle
Activation of protein C and its distribution between its inhibitors, protein C inhibitor, alpha 1-antitrypsin and alpha 2-macroglobulin, in patients with disseminated intravascular coagulation.
pubmed:affiliation
Department of Haematology, Royal Victoria Hospital Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Case Reports, Research Support, Non-U.S. Gov't