Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-6-21
pubmed:abstractText
Lymphocyte trafficking is an essential process in immune and inflammatory functions which can be thought to contain at least two main components: adhesion and migration. Whereas adhesion molecules such as the selections are known to mediate the homing of leukocytes from the blood to the endothelium, the chemoattractant substances responsible for the migration of specific subsets of lymphocytes to sites of infection or inflammation are largely unknown. Here we show that two molecules in the chemokine (for chemoattractant cytokine) superfamily, human macrophage inflammatory protein 1 alpha (MIP-1 alpha) and MIP-1 beta, do not share identical attractant activities for lymphocyte subpopulations. When analyzed in vitro in microchemotaxis experiments, HuMIP-1 beta tends to attract CD4+ T lymphocytes, with some preference for T cells of the naive (CD45RA) phenotype. HuMIP-1 alpha, when tested in parallel with HuMIP-1 beta, is a more potent lymphocyte chemoattractant with a broader range of concentration-dependent chemoattractant specificities. HuMIP-1 alpha at a concentration of 100 pg/ml attracts B cells and cytotoxic T cells, whereas at higher concentrations (10 ng/ml), the migration of these cells appears diminished, and the migration of CD4+ T cells is enhanced. Thus, in this assay system, HuMIP-1 alpha and -1 beta have differential attractant activities for subsets of immune effector cells, with HuMIP-1 alpha having greater effects than HuMIP-1 beta, particularly on B cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1281207, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1370686, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1378073, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1380064, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1569397, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1699135, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1744577, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1760836, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-1910690, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2320111, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2521353, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2567673, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2648569, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2653379, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2677047, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2850067, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2894392, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2926331, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2965180, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2974420, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-2978373, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-3086300, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-3108367, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-3480540, http://linkedlifedata.com/resource/pubmed/commentcorrection/7684437-7679328
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
177
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1821-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.
pubmed:affiliation
Genentech, Inc., South San Francisco, California 94080.
pubmed:publicationType
Journal Article