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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0079427,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1333226,
umls-concept:C1514468,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
7
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pubmed:dateCreated |
1993-4-6
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pubmed:databankReference |
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pubmed:abstractText |
A novel synapse-associated protein, SAP90, accumulates around the axon hillock of Purkinje cells in rat cerebellum. By immuno-electron microscopy, SAP90 has been localized to the presynaptic termini of basket cells forming inhibitory, gamma-aminobutyric acid (GABA)ergic synapses onto Purkinje cell axon hillocks. The amino acid sequence for SAP90 has been deduced from the nucleotide sequence of a series of overlapping cDNA clones. SAP90 is related to the gene product encoded by the Drosophila tumor suppressor gene dlg-A. SAP90 and the dlg-A product share an overall sequence identity of 54%. Three distinct domains can be identified: (i) a potential cytoskeletal region consisting of three repeats of 90 amino acids in length, (ii) a domain with similarity to SH3, a putative regulatory motif found in the src family of non-receptor protein tyrosine kinases and several proteins associated with the cortical cytoskeleton, and (iii) a carboxyl-terminal domain homologous to yeast guanylate kinase. These features suggest a possible role for SAP90 in a guanine nucleotide-mediated signal transduction pathway at a subset of GABAergic synapses in the rat cerebellum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
268
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pubmed:geneSymbol |
dlg-A
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4580-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7680343-Amino Acid Sequence,
pubmed-meshheading:7680343-Animals,
pubmed-meshheading:7680343-Base Sequence,
pubmed-meshheading:7680343-Cerebellum,
pubmed-meshheading:7680343-DNA,
pubmed-meshheading:7680343-Drosophila,
pubmed-meshheading:7680343-Drosophila Proteins,
pubmed-meshheading:7680343-Genes, Tumor Suppressor,
pubmed-meshheading:7680343-Insect Hormones,
pubmed-meshheading:7680343-Molecular Sequence Data,
pubmed-meshheading:7680343-Nerve Tissue Proteins,
pubmed-meshheading:7680343-RNA,
pubmed-meshheading:7680343-Rats,
pubmed-meshheading:7680343-Rats, Sprague-Dawley,
pubmed-meshheading:7680343-Restriction Mapping,
pubmed-meshheading:7680343-Sequence Homology, Amino Acid,
pubmed-meshheading:7680343-Synapses,
pubmed-meshheading:7680343-Tumor Suppressor Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.
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pubmed:affiliation |
Center for Molecular Neurobiology, University of Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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