rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1993-2-24
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pubmed:abstractText |
Insects and other invertebrates use L-glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. In contrast to the well-studied effects of L-glutamate on invertebrate muscle cells, relatively little is known about the physiological role of glutamate receptors (GluRs) in the invertebrate central nervous system. We have applied a molecular cloning approach to elucidate the molecular structure of neuronal and muscle-specific Drosophila glutamate receptor subunits (DGluRs). Several domains conserved between rat GluR subunits and DGluRs indicate regions of high functional significance. Drosophila genetics may now be used as a valuable experimental tool to gain further insight into the role of DGluRs in development, synaptic plasticity and control of gene expression.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:issn |
1023-294X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
234-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7678526-Animals,
pubmed-meshheading:7678526-Cloning, Molecular,
pubmed-meshheading:7678526-Drosophila,
pubmed-meshheading:7678526-Gene Expression,
pubmed-meshheading:7678526-Glutamates,
pubmed-meshheading:7678526-Glutamic Acid,
pubmed-meshheading:7678526-Ion Channels,
pubmed-meshheading:7678526-Macromolecular Substances,
pubmed-meshheading:7678526-Muscles,
pubmed-meshheading:7678526-Nervous System Physiological Phenomena,
pubmed-meshheading:7678526-RNA, Messenger,
pubmed-meshheading:7678526-Rats,
pubmed-meshheading:7678526-Receptors, Glutamate
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular analysis of Drosophila glutamate receptors.
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pubmed:affiliation |
Max-Planck-Institut für Hirnforschung, Abteilung Neurochemie, Frankfurt, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Review
|