|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0008838,
umls-concept:C0015133,
umls-concept:C0205179,
umls-concept:C0205851,
umls-concept:C0238815,
umls-concept:C0871261,
umls-concept:C1274040,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2603343,
umls-concept:C2911692
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1995-10-19
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|
pubmed:abstractText |
A trial was undertaken to assess the efficacy and toxicity of high-dose cisplatin and etoposide in children with newly diagnosed advanced malignant germ cell tumors. A total of eleven children and adolescents were treated with courses of high dose cisplatin 30 mg/m2/day and etoposide 120 mg/m2/day in five day cycles at 21 day intervals. There were eight girls and three boys, aged between 1 and 16 years (median: 120 months). Of nine unresectable tumors, six were in complete remission after three cycles and were completely resected. All patients are alive (median follow-up 17 months). Preliminary results shows that high dose cisplatin and etoposide is effective in controlling advanced malignant germ cell tumor.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
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|
pubmed:issn |
0098-1532
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
25
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
396-9
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:7674997-Adolescent,
pubmed-meshheading:7674997-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7674997-Brazil,
pubmed-meshheading:7674997-Child,
pubmed-meshheading:7674997-Child, Preschool,
pubmed-meshheading:7674997-Cisplatin,
pubmed-meshheading:7674997-Combined Modality Therapy,
pubmed-meshheading:7674997-Disease-Free Survival,
pubmed-meshheading:7674997-Etoposide,
pubmed-meshheading:7674997-Female,
pubmed-meshheading:7674997-Follow-Up Studies,
pubmed-meshheading:7674997-Germinoma,
pubmed-meshheading:7674997-Humans,
pubmed-meshheading:7674997-Infant,
pubmed-meshheading:7674997-Male,
pubmed-meshheading:7674997-Neoplasm Staging,
pubmed-meshheading:7674997-Ovarian Neoplasms,
pubmed-meshheading:7674997-Pilot Projects,
pubmed-meshheading:7674997-Remission Induction,
pubmed-meshheading:7674997-Reoperation,
pubmed-meshheading:7674997-Testicular Neoplasms
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|
pubmed:year |
1995
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|
pubmed:articleTitle |
Response to high-dose cisplatin and etoposide in advanced germ cell tumors in children: results of the Brazilian Germ Cell Tumor Study.
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|
pubmed:affiliation |
Pediatric Department, Hospital A.C. Camargo, São Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
|
