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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1976-4-10
|
| pubmed:abstractText |
B-Lymphocytes carrying IgG-, IgM,- and IgA-surface receptors were estimated by fluorescence microscopy in the palatine tonsil of 50 patients aged 3 to 18 years as well as in 44 patients with various types of malignant lymphoms and lymphoepithelial carcinomas. Hyperplastic tonsillartissue contains large numbers of B-cells with a marked variability in concentration (4-30% IgG-cells, medium 12,9%;6-36 IgM-cells, medium 23.4%;3-38% IgA cells, medium 20.8%). There appears to exist an age-dependent increase in IgM-cells and an increase in IgG-and IgA-cells in patients with numerous recurrent infections of the upper respiratory tract. Malignant lymphomas can be grouped into three main categories: Such with a predominance of one B-cell line (above 75-80% of one immunological cell type); these include primarily malignant lymphomas of the well differentiated lymphocytic type (IgM and IgA receptors). Secondly, such with a significant decrease in B-cells (below 10%) which include primarily malignant lymphomas of the poorly differentiated lymphocytic type. Thirdly, such with an increased B-cell content but with more than one cell line participating in cell proliferation. The latter ones comprise certain cases of Hodkin's lymphomas. Lymphoepithial carcinomas are charactersized by a significant decrease in total B-cell content, except for IgE- and IgD-cells which were not investigated. The results show that the immunologic classification of malignant lymphomas correlates only to a certain degree with the morphologic classification; i.e. the same morphologic type of tumor may possess different immunologic characteristics. Since the immunologic characteristics may reflect a certain functional potential of these tumors as well as probably a certain kind of immunologic incompetence prior to tumor development, it is suggested, that future morphologic investigations of malignant lymphomas and lymphoepithelial carcinomas are combined with immunologic classifications.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0302-9530
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
209
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
291-301
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:766742-Adolescent,
pubmed-meshheading:766742-Adult,
pubmed-meshheading:766742-Age Factors,
pubmed-meshheading:766742-Aged,
pubmed-meshheading:766742-B-Lymphocytes,
pubmed-meshheading:766742-Binding Sites,
pubmed-meshheading:766742-Carcinoma, Squamous Cell,
pubmed-meshheading:766742-Child,
pubmed-meshheading:766742-Child, Preschool,
pubmed-meshheading:766742-Fluorescent Antibody Technique,
pubmed-meshheading:766742-Head and Neck Neoplasms,
pubmed-meshheading:766742-Hodgkin Disease,
pubmed-meshheading:766742-Humans,
pubmed-meshheading:766742-Immunoglobulin A,
pubmed-meshheading:766742-Immunoglobulin G,
pubmed-meshheading:766742-Immunoglobulin M,
pubmed-meshheading:766742-Lymphoma,
pubmed-meshheading:766742-Lymphoma, Follicular,
pubmed-meshheading:766742-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:766742-Lymphoma, Non-Hodgkin,
pubmed-meshheading:766742-Middle Aged,
pubmed-meshheading:766742-Palatine Tonsil
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
[The distribution of B-lymphocytes in lymphoepithelial tissues as well as in tumors of the neck-, nose-, and throat region derived from lymphoreticular and lymphoepithelial tissues (author's transl)].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|