Linked Life Data

7656383

Source:http://linkedlifedata.com/resource/pubmed/id/7656383

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-10-4
pubmed:abstractText
Tumor-infiltrating lymphocytes (TILs) were isolated from 8 solid tumors by means of in vitro digestion and discontinuous density gradient centrifugation. By incubating TILs in the presence of 6000 Iu/ml rIL-2 and 500u/ml rTNF alpha, It's demonstrated that rTFN alpha could enhance the proliferation of TILs, promote the proportion of TILs in S-phase and G2 M-phase, enhance the percentage of CD3+ and CD8+ cells, up-regulate the expression of IL-2R, as well as enhance the cytotoxicity of TILs against autologous and allogenic tumors both in vitro and in vivo. The results are of significance for increasing immunotherapy effects and decreasing the adverse effects of certain cytokines.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0529-5807
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Combined antitumor effect of tumor-infiltrating lymphocytes and tumor necrosis factor alpha].
pubmed:affiliation
Department of Pathology, Beijing Medical University.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't