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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-9-25
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pubmed:abstractText |
Kidney derived MDCK cells are protected from the stress of hypertonicity by accumulating compatible osmolytes. Accumulation of the compatible osmolytes myo-inositol and betaine is driven by hypertonicity-induced stimulation of transcription of the genes coding for the myo-inositol cotransporter and the betaine cotransporter. We tested the importance of the mitogen-activated protein kinase pathway in transcriptional activation of the genes for the two osmolytes cotransporters because this kinase pathway is rapidly activated when cells are exposed to hypertonicity and a mitogen-activated protein kinase pathway is essential for the osmo-protective transcriptional response of yeast to hypertonicity. Eliminating the activation of mitogen-activated protein kinase did not block the hypertonicity induced increase in accumulation of osmolyte transporter mRNA.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
213
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
975-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7654262-Animals,
pubmed-meshheading:7654262-Bacterial Proteins,
pubmed-meshheading:7654262-Betaine,
pubmed-meshheading:7654262-Carrier Proteins,
pubmed-meshheading:7654262-Cell Line,
pubmed-meshheading:7654262-Dogs,
pubmed-meshheading:7654262-Enzyme Activation,
pubmed-meshheading:7654262-Inositol,
pubmed-meshheading:7654262-Membrane Transport Proteins,
pubmed-meshheading:7654262-Protein Kinases,
pubmed-meshheading:7654262-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7654262-Transcription, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
The MAP kinase cascade is not essential for transcriptional stimulation of osmolyte transporter genes.
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pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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