Linked Life Data

7647932

Source:http://linkedlifedata.com/resource/pubmed/id/7647932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-9-26
pubmed:abstractText
Well-differentiated colorectal adenocarcinomas are subclassified into carcinoma with high-grade atypia (CAH) and carcinoma with low-grade atypia (CAL) based on their cellular atypia. It is proposed that CAH and CAL are different in histologic prognostic factors and that the former should be regarded as carcinoma with high-grade malignancy and the latter as low-grade malignancy. In this study, the differences in cell-proliferative activity between CAH and CAL were examined using a monoclonal antibody to the proliferating cell nuclear antigen (PCNA). The PCNA index and mitotic index of 27 early colorectal carcinomas (9 CAL, 5 CAH, and 13 carcinomas with mixed low- and high-grade atypia) was evaluated in relation to their depth of invasion. In intramucosal lesions, both indices were higher in CAH (78%, 0.89%) than in CAL (68%, 0.47%; P < 0.01). In lesions invading into the submucosa, the PCNA and mitotic indices were also higher in CAH (75%, 0.65%) than in CAL (35%, 0.19%; P < 0.01). A significant correlation was observed between the PCNA index and the mitotic index in the mucosal lesions (P < 0.05). These results indicate that CAH has a higher proliferative activity than CAL, and support the current authors' proposal that CAH is a high-grade malignancy and CAL low-grade malignancy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1320-5463
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-65
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The proliferating cell nuclear antigen (PCNA) index correlates with the grade of cytologic atypia in well-differentiated early adenocarcinomas of the large intestine.
pubmed:affiliation
First Department of Pathology, Niigata University School of Medicine, Japan.
pubmed:publicationType
Journal Article