Linked Life Data

7633438

Source:http://linkedlifedata.com/resource/pubmed/id/7633438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-9-14
pubmed:abstractText
Meiotic recombination is a specifically timed and regulated process which does not occur randomly throughout the genome, but tends to be clustered in 'hotspots'. There is extensive evidence that recombination rate is influenced by chromatin conformation and that events are primarily initiated at gene promoter regions. In an effort to determine the pattern of chromatin condensation and recombination at meiosis in an imprinted region, fine scale genetic mapping in the approximately 4 Mb Prader-Willi/Angelman syndrome deletion region was undertaken. The results indicate that the male-female recombination ratio can vary significantly over short regions. A male recombination hotspot is localized to between the 3' end of GABRA5 and D15S156, which is adjacent to but outside the putative AS/PWS imprinted regions. In addition, a region of relatively high recombination in females is observed between D15S128 and D15S97, which spans a domain of paternal allele-specific transcription implicated in the Prader-Willi syndrome. It is inferred that the inactivation and relative condensation of this latter region on the maternal chromosome occurs as a post-meiotic modification.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0964-6906
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
801-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Sex-specific meiotic recombination in the Prader--Willi/Angelman syndrome imprinted region.
pubmed:affiliation
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't