| pubmed-article:7618106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7618106 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:7618106 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:7618106 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:7618106 | lifeskim:mentions | umls-concept:C0969709 | lld:lifeskim |
| pubmed-article:7618106 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:7618106 | pubmed:issue | 5222 | lld:pubmed |
| pubmed-article:7618106 | pubmed:dateCreated | 1995-8-18 | lld:pubmed |
| pubmed-article:7618106 | pubmed:abstractText | The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli. | lld:pubmed |
| pubmed-article:7618106 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7618106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7618106 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7618106 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:7618106 | pubmed:author | pubmed-author:ShorrGG | lld:pubmed |
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| pubmed-article:7618106 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7618106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7618106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7618106 | pubmed:pagination | 403-7 | lld:pubmed |
| pubmed-article:7618106 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7618106 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7618106 | pubmed:articleTitle | Integration of MAP kinase signal transduction pathways at the serum response element. | lld:pubmed |
| pubmed-article:7618106 | pubmed:affiliation | Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA. | lld:pubmed |
| pubmed-article:7618106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7618106 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7618106 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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