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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5222
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pubmed:dateCreated |
1995-8-18
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pubmed:abstractText |
The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Response Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ets-Domain Protein Elk-1,
http://linkedlifedata.com/resource/pubmed/chemical/ets-Domain Protein Elk-4
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7618106-Animals,
pubmed-meshheading:7618106-CHO Cells,
pubmed-meshheading:7618106-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:7618106-Cricetinae,
pubmed-meshheading:7618106-DNA-Binding Proteins,
pubmed-meshheading:7618106-Gene Expression Regulation,
pubmed-meshheading:7618106-Interleukin-1,
pubmed-meshheading:7618106-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:7618106-MAP Kinase Kinase 1,
pubmed-meshheading:7618106-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:7618106-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:7618106-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:7618106-Mitogen-Activated Protein Kinases,
pubmed-meshheading:7618106-Nuclear Proteins,
pubmed-meshheading:7618106-Phosphorylation,
pubmed-meshheading:7618106-Promoter Regions, Genetic,
pubmed-meshheading:7618106-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7618106-Protein-Tyrosine Kinases,
pubmed-meshheading:7618106-Proto-Oncogene Proteins,
pubmed-meshheading:7618106-Serum Response Factor,
pubmed-meshheading:7618106-Signal Transduction,
pubmed-meshheading:7618106-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7618106-Transcription Factors,
pubmed-meshheading:7618106-Transfection,
pubmed-meshheading:7618106-ets-Domain Protein Elk-1,
pubmed-meshheading:7618106-ets-Domain Protein Elk-4
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pubmed:year |
1995
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pubmed:articleTitle |
Integration of MAP kinase signal transduction pathways at the serum response element.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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