| pubmed-article:7615724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C1622968 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0206708 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0005558 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0079941 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0441800 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C1548673 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7615724 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7615724 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7615724 | pubmed:dateCreated | 1995-8-18 | lld:pubmed |
| pubmed-article:7615724 | pubmed:abstractText | The proteins encoded by the human papillomavirus type 16 E6-E7 open reading frame are essential for transformation of the host cell. Two mRNA species, E6*I and E6*II, generated by alternative splicing of a polycistronic pre-mRNA, encode truncated E6 proteins and the E7 protein. Our investigation assessed whether or not the level of expression of E6*I and E6*II varies quantitatively in relation to the grade of cervical intraepithelial neoplasia (CIN). We used a quantitative reverse transcription PCR assay to quantify these transcripts in concurrently collected biopsy tissue and exfoliated cervical cells from 22 women with a normal cervix or various grades of CIN. We evaluated transcription profiles in relation to CIN grade and specimen type. The expression levels of E6*I and E6*II in exfoliated cervical cells did not vary significantly in relation to the grade of CIN. However, expression of E6*II was significantly diminished or absent in biopsy tissue obtained from CIN grade II and III lesions (P = 0.014). Our findings suggest that quantification of E6*I and E6*II expression in biopsy tissue may be more clinically relevant than analysis of exfoliated cells. The identification of distinct patterns of expression in association with low- and high-grade CIN suggests that quantification of E6*I and E6*II expression in biopsy tissue may have prognostic value as an indicator of CIN progression. | lld:pubmed |
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| pubmed-article:7615724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7615724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7615724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7615724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7615724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7615724 | pubmed:month | May | lld:pubmed |
| pubmed-article:7615724 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:7615724 | pubmed:author | pubmed-author:WayneSS | lld:pubmed |
| pubmed-article:7615724 | pubmed:author | pubmed-author:ParaskevasMM | lld:pubmed |
| pubmed-article:7615724 | pubmed:author | pubmed-author:GuijonFF | lld:pubmed |
| pubmed-article:7615724 | pubmed:author | pubmed-author:McNicolPP | lld:pubmed |
| pubmed-article:7615724 | pubmed:author | pubmed-author:HidajatRR | lld:pubmed |
| pubmed-article:7615724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7615724 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:7615724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7615724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7615724 | pubmed:pagination | 1169-73 | lld:pubmed |
| pubmed-article:7615724 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7615724 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7615724 | pubmed:articleTitle | Expression of human papillomavirus type 16 E6-E7 open reading frame varies quantitatively in biopsy tissue from different grades of cervical intraepithelial neoplasia. | lld:pubmed |
| pubmed-article:7615724 | pubmed:affiliation | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada. | lld:pubmed |
| pubmed-article:7615724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7615724 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7615724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7615724 | lld:pubmed |
